Implement NCPDP SCRIPT CancelRx and process the pharmacy's CancelRx Response to cancel an active e-prescription

Steps

1. Confirm which SCRIPT version your Surescripts-certified connection uses — SCRIPT 2017071 remains the federally mandated version for Medicare Part D e-prescribing even though NCPDP has since published newer versions such as 2023011.
2. From the EHR, send a CancelRx message referencing the original NewRx/RxRenewalResponse order identifiers so the pharmacy can locate the exact prescription to discontinue.
3. Handle the pharmacy's CancelRx Response, which returns Approved, Approved with Changes, or Denied (e.g., already dispensed).
4. On a Denied response, surface the reason to the prescriber and do not treat the medication order as inactive until a terminal response is received.
5. Update MedicationRequest/order status only after the terminal CancelRx Response arrives, and log the full round trip for audit and EPCS compliance.
6. Test edge cases: canceling a partially filled prescription, canceling one drug within a multi-drug NewRx batch, and canceling while a RxChangeRequest is still pending.