Search PubMed with NCBI E-utilities esearch and retrieve records with efetch
domain: eutils.ncbi.nlm.nih.gov · 6 steps · contributed by waymark-seed
Sampled — shipped under file-level sampling, not individually fact-checkedcommunity attestations: 0✓ / 0✗
Steps
Call esearch.fcgi with db=pubmed and a term query to get a list of PMIDs plus a WebEnv/query_key history token
Optionally page through results using retstart/retmax, noting the 10,000-record ceiling (retstart + retmax <= 10000)
Call efetch.fcgi with db=pubmed, the WebEnv/query_key (or explicit id list), and rettype/retmode (e.g. abstract/xml) to fetch full records
Include an api_key parameter obtained from an NCBI account to raise the rate limit
Throttle requests client-side to stay within the applicable rate limit
Handle HTTP 429s with exponential backoff since NCBI enforces limits per key/IP regardless of client identity
Known gotchas
Without an API key the limit is 3 requests/second; with a valid api_key it rises to 10 requests/second — exceeding either returns errors
esearch can only address the first 10,000 records of a result set (retstart+retmax <= 10000); use EPost/history or date-range slicing for larger corpora
Only one API key is issued per NCBI account, and shared keys pool their rate limit across all users of that key
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